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Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Frontiers of Medicine 2014, Volume 8, Issue 1,   Pages 17-23 doi: 10.1007/s11684-014-0313-7

Abstract: In addition to the recent progress in antiviral treatment, therapeutic vaccination is a promising newthis paper presents the peptide and protein-based, DNA-based, cell-based, and antigen-antibody-based therapeuticThe advantages, disadvantages, and future perspectives for these therapeutic vaccines are discussed.

Keywords: chronic hepatitis B     therapeutic     antigen-antibody complexes     DNA     vaccine    

Experimental Studies on Recombinant Hepatitis B Immunogenic Complex Therapeutic Vaccine (YIC)

Wenyu mei,He Lifang,Qu Di,Ma Zhangmei,Yao Xin

Strategic Study of CAE 1999, Volume 1, Issue 1,   Pages 38-42

Abstract:

A therapeutic vaccine composed of HBsAg complexed to anti-HBs (IC) has been developed for viral hepatitisEnhanced immune response was induced in hosts immunized with this complex, and the mechanisms of this vaccineFor human use, a therapeutic vaccine composed of yeast-derived recombinant HBsAg complexed to human high-titer

Keywords: hepatitis B     therapeutic vaccine     antigen-antibody complex     immune responses    

Innovation-driven trend shaping COVID-19 vaccine development in China

Frontiers of Medicine doi: 10.1007/s11684-023-1034-6

Abstract: we outline representative vaccines in multiple routes, while the merits and plights of the existing vaccine

Keywords: SARS-CoV-2     COVID-19 vaccine     vaccine development    

Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 6,   Pages 973-984 doi: 10.1007/s11705-021-2123-1

Abstract: To increase antibody secretion and dose sparing, squalene-in-water aluminium hydrogel (alum)-stabilised emulsions (ASEs) have been developed, which offer increased surface areas and cellular interactions for higher antigen loading and enhanced immune responses. Nevertheless, the squalene (oil) in previous attempts suffered from limited oxidation resistance, thus, safety and stability were compromised. From a clinical translational perspective, it is imperative to screen the optimal oils for enhanced emulsion adjuvants. Here, because of the varying oleic to linoleic acid ratio, soybean oil, peanut oil, and olive oil were utilised as oil phases in the preparation of aluminium hydrogel-stabilised squalene-in-water emulsions, which were then screened for their stability and immunogenicity. Additionally, the underlying mechanisms of oil phases and emulsion stability were unravelled, which showed that a higher oleic to linoleic acid ratio increased anti-oxidative capabilities but reduced the long-term storage stability owing to the relatively low zeta potential of the prepared droplets. As a result, compared with squalene-in-water ASEs, soybean-in-water ASEs exhibited comparable immune responses and enhanced stability. By optimising the oil phase of the emulsion adjuvants, this work may offer an alternative strategy for safe, stable, and effective emulsion adjuvants.

Keywords: pickering emulsion     vaccine adjuvant     alum-stabilised emulsion     oleic to linoleic acid ratio     stability    

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Frontiers of Medicine 2008, Volume 2, Issue 1,   Pages 51-57 doi: 10.1007/s11684-008-0010-5

Abstract: After subcutaneous injection with SART3 gene vaccine, cytotoxic T lymphocyte (CTL) activity was measuredAnother group was treated with the vaccine after tumor implantation.It was found that human SART3 DNA vaccine can elicit a specific CTL reaction from the mouse splenocytesThe vaccine also shows activity in tumor treatment.We conclude that the human SART3 DNA vaccine can induce antitumor ability against tumor cells expressing

Keywords: antitumor therapy     occurrence     implantation     DNA vaccine     SART3 DNA    

Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Strategic Study of CAE 2021, Volume 23, Issue 4,   Pages 153-161 doi: 10.15302/J-SSCAE-2021.04.018

Abstract: the urgent needs of coronavirus disease 2019 (COVID-19) epidemic prevention and control, nucleic acid vaccinehas attracted great attention in the vaccine research and development (R&D) field owing to its highParticularly, the R&D process of messenger RNA (mRNA) vaccine has significantly accelerated, andthe mRNA vaccine was approved for the first time to be marketed and used in humans.Subsequently, it analyzes the impact of COVID-19 outbreak on the mRNA vaccine research, summarizes the

Keywords: nucleic acid vaccine     deoxyribonucleic acid (DNA) vaccine     ribonucleic acid (RNA) vaccine     messengerRNA (mRNA) vaccine     coronavirus disease 2019 (COVID-19)     cancer    

Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 404-418 doi: 10.1007/s11684-014-0379-2

Abstract: functions of circulating miRNAs in cardiovascular system but also inform the development of miRNAs therapeuticthe potential roles of circulating miRNAs in a variety of cardiovascular diseases from biomarkers to therapeutic

Keywords: microRNA     cardiovascular disease     biomarkers     therapeutic target    

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Frontiers of Medicine 2020, Volume 14, Issue 1,   Pages 30-42 doi: 10.1007/s11684-019-0721-9

Abstract: Remarkable progress has been achieved for prophylactic and therapeutic interventions against human immunodeficiencyHowever, vaccine development has remained challenging.in broadly neutralizing monoclonal antibodies (bNAbs) has led to the development of multiple novel vaccineOur review aims to highlight these discoveries and rejuvenate our endeavor in HIV-1 vaccine design and

Keywords: HIV-1     broadly neutralizing antibodies     Env conformational states     vaccine design     SOSIP    

Brown and beige fat: the metabolic function, induction, and therapeutic potential

Shuwen Qian,Haiyan Huang,Qiqun Tang

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 162-172 doi: 10.1007/s11684-015-0382-2

Abstract: induce the development, the activation of brown or beige adipose tissue, which seem to be promising for therapeutic

Keywords: brown adipocyte     beige adipocyte     metabolism     obesity    

Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective

Frontiers of Medicine   Pages 867-877 doi: 10.1007/s11684-023-0995-9

Abstract: The protection against SARS-CoV-2 infection of the Sinopharm vaccine was similar in participants with

Keywords: COVID-19     Sinopharm/BBIBP vaccine     immunocompromised patients     real-world    

Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques

Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,

Frontiers of Medicine 2010, Volume 4, Issue 1,   Pages 36-42 doi: 10.1007/s11684-010-0020-y

Abstract: Vulnerable atherosclerotic plaque rupture leading to thrombosis is the major cause of acute coronary syndrome (ACS). Studies on the pathophysiologic mechanism of both ACS and plaque stabilizing treatment are driving the development of animal models of vulnerable plaque. In our laboratory, we established animal models of plaque rupture and thrombosis in rabbits and mice that are similar to human plaque rupture. Potential mechanisms involved in plaque vulnerability were studied from the inflammation-immunity, proliferation-apoptosis, oxidative stress and biomechanics aspects. Imaging markers and biomarkers were used to detect vulnerable plaques, including high frequency duplex ultrasound, intravascular ultrasound (IVUS), intravascular ultrasound elastography, magnetic resonance imaging (MRI) and inflammatory markers. Effective gene and drug strategies to treat vulnerable plaques were explored.

Keywords: vulnerable plaque     animal models     mechani-sm     detection     treatment    

Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

Frontiers of Medicine 2020, Volume 14, Issue 2,   Pages 117-125 doi: 10.1007/s11684-020-0773-x

Abstract: the insights in the virus, the responses of the host cells, the cytokine release syndrome, and the therapeutic

Keywords: COVID-19     SARS-CoV-2     pathogenesis     evidence-based medicine     control and therapeutic strategies    

Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate vaccine

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Frontiers of Medicine 2016, Volume 10, Issue 4,   Pages 490-498 doi: 10.1007/s11684-016-0470-y

Abstract: and protective immunity of a Hemophilus influenzae b (Hib) polysaccharide conjugate vaccineA total of 15 young mice aged 3 weeks to 5 weeks were immunized with the conjugate vaccine, and another15 young mice of the same age were immunized with the licensed Hib-tetanus toxoid (TT) vaccine.This new Hib-PsaA conjugate vaccine can induce both anti-PsaA and anti-Hib immune responses in young

Keywords: conjugate vaccine     pneumococcal surface adhesin A     Hemophilus influenzae b     immunogenicity     otitis media    

Review on Drug Regulatory Science Promoting COVID-19 Vaccine Development in China Review

Zhiming Huang, Zhihao Fu, Junzhi Wang

Engineering 2022, Volume 10, Issue 3,   Pages 127-132 doi: 10.1016/j.eng.2022.01.001

Abstract: This review summarizes the overall state of the vaccine industry, research and development (R&D)Ultimately, this review provides a reference for the formulation of a vaccine development strategy inresponse to the current pandemic and the field of vaccine development in the post-pandemic era, as well

Keywords: Regulatory science     COVID-19 vaccine     Vaccine industry    

virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 480-489 doi: 10.1007/s11684-017-0594-8

Abstract: Thus, a successful HIV-1 vaccine likely needs to induce more potent and broader immune responses thanif superinfection can lead to cross-reactive immune responses will be highly informative for HIV-1 vaccine

Keywords: human immunodeficiency virus type I     superinfection     incidence     immune response    

Title Author Date Type Operation

Vaccine therapies for chronic hepatitis B: can we go further?

Yumei Wen, Xuanyi Wang, Bin Wang, Zhenhong Yuan

Journal Article

Experimental Studies on Recombinant Hepatitis B Immunogenic Complex Therapeutic Vaccine (YIC)

Wenyu mei,He Lifang,Qu Di,Ma Zhangmei,Yao Xin

Journal Article

Innovation-driven trend shaping COVID-19 vaccine development in China

Journal Article

Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine

Journal Article

Antitumor immunity of human SART3 gene vaccine against mouse tumor

HE Yu, YANG Shuhua, LIU Yong, LI Tao

Journal Article

Development Trends and Suggestions of Nucleic Acid Vaccines

Li Aihua, Yang Xuemei, Sun Yinan, Yuan Yakun, Yang Juntao

Journal Article

Circulating microRNAs in cardiovascular diseases: from biomarkers to therapeutic targets

Feng Wang,Chen Chen,Daowen Wang

Journal Article

Broadly neutralizing antibodies and vaccine design against HIV-1 infection

Qian Wang, Linqi Zhang

Journal Article

Brown and beige fat: the metabolic function, induction, and therapeutic potential

Shuwen Qian,Haiyan Huang,Qiqun Tang

Journal Article

Protection of inactivated vaccine against SARS-CoV-2 infections in patients with comorbidities: a prospective

Journal Article

Molecular mechanisms and therapeutic strategies of vulnerable atherosclerotic plaques

Wen-Qiang CHEN MD, Yun ZHANG MD, PhD, FACC,

Journal Article

Advances in COVID-19: the virus, the pathogenesis, and evidence-based control and therapeutic strategies

Guangbiao Zhou, Saijuan Chen, Zhu Chen

Journal Article

Immunogenicity and protective immunity against otitis media caused by pneumococcus in mice of Hib conjugate vaccine

Zeyu Chen,Rong Guo,Jianghong Xu,Chuangjun Qiu

Journal Article

Review on Drug Regulatory Science Promoting COVID-19 Vaccine Development in China

Zhiming Huang, Zhihao Fu, Junzhi Wang

Journal Article

virological characteristics of human immunodeficiency virus type 1 superinfection: implications in vaccine

Yang Gao, Wen Tian, Xiaoxu Han, Feng Gao

Journal Article